ASPERGILLOSE BRONCHOPULMONAIRE ALLERGIQUE PDF

Introduction Nous inhalons quotidiennement des spores aspergillaires. Tableau 3. Figure 2. CGD : chronic granulomatous disease. Corey Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Ader Invasive pulmonary aspergillosis in chronic obstructive pulmonary disease : An emerging fungal pathogen.

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Article gratuit. Abstract Allergic bronchopulmonary aspergillosis revealing cystic fibrosis In predisposed patients, allergic bronchopulmonary aspergillosis ABPA can arise from aspergillus bronchial colonization.

We report the case of a young woman who presented with a right basal pneumonia, ground glass opacities and mediastinal adenopathies on CT scan. Biological, radiological and clinical criteria, as well as an history of childhood asthma, allowed the initial diagnosis of ABPA. However, the unusual coexistence of an additional infection with Pseudomonas Aeruginosa evoked the diagnosis of cystic fibrosis, confirmed by a sweat test and genetic analysis. Under corticosteroid and antifungal therapy and antibiotics, the clinical and radiological evolution was favourable but immuno-allergic sensitisation persisted.

This variability is partly explained by the difficulty of the diagnosis due to confounding clinical, radiological, and biological signs between ABPA and cystic fibrosis. Many predictive development factors of ABPA in the context of cystic fibrosis have been reported, including respiratory function, personal or familial atopy, colonization with Pseudomonas Aeruginosa and age. As in non cystic fibrosis patients, the treatment requires systemic corticotherapy and itraconazole.

ABPA is still often under diagnosed and should be evoked in the context of cystic fibrosis.

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