Abstract Moderate hyperhomocysteinemia and atherothrombosis. Elevated levels of plasma total homocys- teine are now accepted as an independent risk factor for premature atherosclerosis. Nutritional, environmental and genetic factors may contribute to increase the levels of homocysteine. The exact pathogenesis of vascular damage induced by homocysteine is still not completely understood.
|Published (Last):||16 December 2013|
|PDF File Size:||8.99 Mb|
|ePub File Size:||14.89 Mb|
|Price:||Free* [*Free Regsitration Required]|
Abstract Moderate hyperhomocysteinemia and atherothrombosis. Elevated levels of plasma total homocys- teine are now accepted as an independent risk factor for premature atherosclerosis. Nutritional, environmental and genetic factors may contribute to increase the levels of homocysteine. The exact pathogenesis of vascular damage induced by homocysteine is still not completely understood. Various mechanisms have been proposed, including a significant prooxidative activity, a stimulation of smooth muscle cells proliferation and an endothelial dysfunction.
Folate, pyridoxine and cyanocobalamin are important cofactors for homocysteine metabolism. In most cases, elevated homocysteine can be reduced by administration of vitamin supplements. It has not yet been demonstrated that reduction in mortality and morbidity can be achieved with these regimens.
However, food supplementation with folic acid has been recommended for treatment or prevention of homocysteine-related disorders in the North American population. Appropriate clinical trials are needed to evaluate the effect of lowering moderate homocysteine levels on atherosclerosis. Cristina R. En uno de estos estudios, el Fra-mingham Heart Study, se evaluaron individuos de ambos sexos No se ha establecido la dosis de vitaminas a utilizarse ni las posibles combinaciones a administrar de las mismas.
Rosenberg IH. Homocysteine, vitamins and arterial occlusive disease: an overview. J Nutr ; Suppl 4 : S-7S. Disorders of transsulfuration. In: Stanbury JB, et al. The metabolic basis of inherited disease. New York McGraw-Hill ; McCully KS. Vascular pathology of homocysteinemia: implications for the development of arteriosclerosis. Am J Pathol ; Thermolabil 5, methylene-tetrahydrofolate reductase as a cause of mild hyperho-mocysteinemia.
Am J Hum Genet ; Homocysteine and marginal vitamin deficiency. The importance of adequate vitamina intake. JAMA ; Homocysteine and hemostasis: pathogenetic mechanisms predisposing to thrombosis. J Nutr ; S-9S. Sangre ; Abnormally high thromboxane biosynthesis in homozygous homocystinuria. J Clin Invest ; Plasma homocysteine and cardiovascular disease mortality. Lancet ; Plasma homocysteine levels and mortality in patients with coronary artery disease.
N Engl J Med ; A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Carotid artery intimal-medial wall thickening and plasma homocysteine in asymptomatic adults. The atherosclerosis risk in communities study. Circulation ; Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis.
High prevalence of hyperhomocysteinemia in patients with juvenile venous thrombosis. Arterioscler Thromb ; Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis? Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. Vitamins as homocysteine-lowering agents.
J Nutr ; SS.
Qué es la hiperhomocisteinemia, conocer sus causas, síntomas, tratamiento, diagnóstico
The co-existence of 9 risk factors portended death in one third of the patients, and all the patients with more than 10 risk factors died. There was a problem providing the content you requested The wave friction factor is commonly expressed as a function of the horizontal water particle semi-excursion A wb at the top of the boundary layer. P-incorporation into the HMS-Ti material led to an overall increase in HDS activity and the hydrogenation ability of the sulfided catalysts. La prueba de la sobrecarga oral a la metionina se utiliza para ponerla en evidencia.
Hiperhomocisteinemia. Causas. Síntomas Diagnostico Tratamiento