Treatment What is Peliosis Hepatis? Peliosis hepatis can be defined as a rare and common medical condition, in which the liver presents multiple cavities that are filled with blood. This is a vascular condition, characterized by the random distribution of the previously-mentioned cavities. It is a known fact that the cavities can have varied diameters few mm — 3 cm.
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There may be occur on other organs. There may be occur on other organs like spleen, bone marrow, lungs, and abdominal lymph nodes Downes et al. Also, spontaneous hepatic rupture, occur during pregnancy in a patient with peliosis hepatis Cimbanassi et al.
Peliotic lesions show a loss of endothelial lining and replaced by perisinusoidal reticulin network. Peliosis hepatis can be caused by a wide array of factors, including chemicals, infections and drugs as recently recorded that Hepatorenal peliosis a characteristic feature of gentamox antibiotic induce toxicity in albino rats Elalfy et al. Hepatic peliosis named spongiosis hepatis is a spontaneously occurring lesion in the livers of ageing rats, appearing most often in the second year of life, with a strong predilection for male animals.
The lesion is composed of altered sinusoidal lining cells which some authors have interpreted as hepatic stellate cells Ito cells or fat-storing cells.
The characteristic histological appearance is described by Bannasch et al. In contrast, electron microscope scanning revealed that hepatic stellate cells become enlarged and show apoptosis in space of dis under effect of gadolinium chloride and diethylnitrosamine induced hepatocellular carcinoma treated balb-c mice El-hadidy et al.
So may be enlarged HSC responsible of widening sinusoidal space, collection of blood into small cavities and share in peliosis mechanism. Also, Elalfy et al. Walker et al. Microscopically, there were two different types of peliosis can be identified in the liver: first type, parenchymal peliosis, composed of irregular cavities that outer lining was not be sinusoidal cells or fibrous tissue; and the second one, phlebectatic peliosis, was regular, spherical cavities protected by endothelium or fibrosis Tsokos et al.
The causes of peliosis hepatica is unknown and it occasionally observed in human liver Craiget et al. Knockdown of endothelial Fas sufficiently recapitulated the protection against hemorrhage seen with the addition of mural cells.
Moreover, HGF is a potent angiogenic factor in vitro and in vivo Bussolino et al. Some of HCCs in Hepatocyte growth factor transgenic mice treated with diethyl nitrosamine were accompanied peliosis-like change Horiguchi et al.
The most consistent abnormality of HGF knockout mice was a loosened liver structure with enlarged sinusoidal spaces and dissociation of the parenchymal cells.
The dissociated cells often showed signs of apoptosis Shiota et al. Notably, importance of TGF-beta signaling in the control of liver homeostasis and there was no peliosis seen in histology feature of c-Met cyto-Met and c-Myc transgenic model Amicone et al. The HCCs observed in c-myc transgenic mice were either of the trabecular or of the solid histological type, varying from well differentiated to poorly differentiated tumors with cell polymorphism, atypia and areas of hemorrhagic necrosis Thorgeirsson et al.
Also, c-Met, a growth factor receptor tyrosine kinase a cell survival mechanism , directly binds to and sequesters the death receptor Fas in hepatocytes. This interaction prevents Fas self-aggregation and Fas ligand binding, thus inhibiting Fas activation and apoptosis Wong et al. Fas and loss of hepatocyte growth factor, a potent hematopoietic agent, may be among the factor enhanced peliosis occurrence and complex interplay of pro-apoptotic signals and have been shown to be Fas mediated Feldmann et al.
As Fas was strongly induced in HCC of transgenic mice that had peliosis feature histological , at least in part, by Fas mediated apoptosis of hepatic cells or epidermal growth factor receptor mediated CD95 tyrosine phosphorylation for formation of death disc, the death-inducing signaling complex Reinehr et al.
The protective agent against peliosis was recorded in rat intoxication with cadmium chloride Tzirogiannis et al. Putrescine considered a major protective effect on hepatocytes, whereas the protective effect of VEGF was more significant for nonparenchymal liver cells Tzirogiannis et al.
Additionally, The hepatoprotective effect of Hepatic Stimulator Substance against cadmium-induced necrosis, apoptosis, and peliosis Tzirogiannis et al. In contrast, excessive VEGF could be playing an etiologic role of VEGF-induced syndrome resembles peliosis hepatis, suggested by the correlation between rising serum VEGF levels and the severity of the liver pathology, a rare human condition that is happened in the setting of advanced malignancies, high-dose androgen therapy and Bartonella henselae infection Wong et al.
Similarly, liver peliosis occurred in follicular lymphoma with a rise in vascular endothelial growth factor and anaemia of inflammation De la Mano et al.
Cirrosis: síntomas y causas de esta enfermedad hepática
A Sara, mi esperanza.. AGelasio, el amor.. A Martba y Arturo, los pilares, la fortaleza.. Esto corresponde al 6. Algunos observadores han clasificado a la peliosis.
Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature. Br J Sports Med ; Universo o Mr. Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann Intern Med ; 2. Impact and evolution of peliosis hepatis in renal transplant recipients.