THEVETIA PERUVIANA PDF

Abstract Intentional self-poisonings with seeds from the yellow oleander tree Thevetia peruviana are widely reported. Two recent randomised controlled trials RCTs assessing the efficacy of activated charcoal reported conflicting outcomes in terms of mortality. The effect of activated charcoal on the pharmacokinetics of Thevetia cardenolides has not been assessed. This information may be useful for determining whether further studies are necessary. The concentration of Thevetia cardenolides was estimated using a digoxin immunoassay. The effect of activated charcoal on cardenolide pharmacokinetics was compared between treatment groups using the AUC24, the 24h Mean Residence Time MRT24 , and regression lines obtained from serial concentration points adjusted for exposure.

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Abstract Intentional self-poisonings with seeds from the yellow oleander tree Thevetia peruviana are widely reported. Two recent randomised controlled trials RCTs assessing the efficacy of activated charcoal reported conflicting outcomes in terms of mortality.

The effect of activated charcoal on the pharmacokinetics of Thevetia cardenolides has not been assessed. This information may be useful for determining whether further studies are necessary. The concentration of Thevetia cardenolides was estimated using a digoxin immunoassay. The effect of activated charcoal on cardenolide pharmacokinetics was compared between treatment groups using the AUC24, the 24h Mean Residence Time MRT24 , and regression lines obtained from serial concentration points adjusted for exposure.

Erratic and prolonged absorption patterns were noted in each patient group. The apparent terminal half-life was highly variable, with a median time of There was a reduction in MRT24 and the apparent terminal half-life estimated from linear regression in patients administered activated charcoal compared to the control group NoAC.

Activated charcoal appears to favourably influence the pharmacokinetic profile of Thevetia cardenolides in patients with acute self-poisoning, which may have clinical benefits. Given the conflicting clinical outcomes noted in previous RCTs, this mechanistic data supports the need for further studies to determine whether a subgroup of patients eg. Keywords: Thevetia, oleander, pharmacokinetic, poisoning, activated charcoal Introduction The yellow oleander tree Thevetia peruviana, previously T.

These cardenolides are structurally similar to the digitalis cardenolides derived from foxglove Figure 1.

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Locations within which Thevetia peruviana is naturalised include many Pacific Islands Introduced, naturalised or invasive in East Africa Thevetia peruviana is naturalised in parts of Kenya A. Witt pers. Habitat Thevetia peruviana can be found in pastures, in savanna and in riparian zones banks of watercourses. Description Thevetia peruviana is a small ornamental tree which grows to about 1. The leaves are spirally arranged, linear and about cm in length Samal et al. All parts of the plant contain the milky juice. Reproduction and dispersal This plant reproduces by seed.

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On All Specimen Trees. More information. In fact, it thrives in the heat and will bloom in the heat all year long if the winters are warm. With full sun and low to moderate water use once established, this low maintenance evergreen tree is sure to be a perfect addition to your landscape. This Southwestern favorite is often used for hedge screens, adding a colorful privacy screen to a variety of landscape styles. This is a fantastic tree for use in groups and shrub border. Yellow Oleander can grow quickly and once the flowers bloom, expect pollinators and hummingbirds to flock into your landscape area.

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Thevetia peruviana

Description[ edit ] Cascabela thevetia is an evergreen tropical shrub or small tree. Its leaves are willow-like, linear-lanceolate, and glossy green in color. They are covered in waxy coating to reduce water loss typical of oleanders. The long funnel-shaped sometimes-fragrant yellow less commonly apricot, sometimes white flowers are in few-flowered terminal clusters. It is effectively drought resistant and tolerant to high temperatures, hence found in various states of India like Bihar , Delhi , Gujarat , Madhya Pradesh , West Bengal , Rajasthan , Tamil Nadu and Uttar Pradesh where semi arid climate is prevalent. Religious importance[ edit ] Its bright yellow flowers are used for religious purposes, especially in the worshipping of the Hindu deity Shiva.

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